Instead of most stories where a question is presented and an answer is searched for, in Homestuck, answers are freely revealed while the reader has no idea that it is an answer to anything or what sort of question it could be answering.
It is backwards.
When the question is finally revealed later in the story, the reader is reminded of the answer being presented to them way back when absolutely nothing made sense, and the entire plot begins to fall into place.
The answers are often cryptic, subtle, or too obvious and ongoing for most to evenconsider them important.
Everything seems to have some sort of meaning and each tiny detail seems to be some sort of important key to completely unlocking and understanding the big picture.
After years of reading Homestuck, the fandom has finally gotten the hang of deciphering such an insane puzzle of a story.
For example, if a banana was randomly placed in a panel, part of the fandom would speculate as to what the significance of the banana could possibly be, part of the fandom would attempt to prove that it is in fact not a banana, and part of the fandom would make a sexual joke.